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KMID : 1094020140310030258
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Journal of Veterinary Clinics
2014 Volume.31 No. 3 p.258 ~ p.261
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Porcine Circovirus Type 2 Infection in a Piglet Born from a Surrogate Mother
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Lee Su-Hyung
Park Jun-Won
Chung Hee-Chun
Park Bong-Kyun
Kim Dae-Yong
Kim Jae-Hoon
Kang Sang-Chul
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Abstract
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A 4-week-old male piglet being maintained in a research facility was found dead without any previousclinical signs. The piglet had been born from a surrogate mother after somatic nuclear transfer as part of axenotransplantation study. Ovaries for nuclear transfer were obtained from a private farm outside the research facility. Histopathologically, multifocal to coalescing granulomatous myocarditis was observed in the heart, characterized byinfiltration of lymphocytes, macrophages and multinucleated giant cells, and by myocardial necrosis and fibrosis. Lymphoid tissues showed marked lymphoid depletion with infiltration by histiocytes or giant cells. Immunohistochemistryshowed PCV-2 antigens in necrotic myocytes, macrophages and multinucleated giant cells in the heart, aswell as in macrophages and giant cells in lymphoid depleted areas of lymphoid tissues. Reproductive failure associatedwith PCV-2 in aborted or stillborn piglets is frequently characterized by myocarditis, and similar lesions were observedin this 4-week-old piglet with PCV-2 infection. The PCV-2 infection in this piglet may have been due to contaminationor infection of an ovary from the pig farm.
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KEYWORD
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myocarditis, ovary, porcine circovirus type 2, somatic nuclear transfer
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